Narcotic antagonists: naltrexone pharmacochemistry and sustained-release preparations.
نویسندگان
چکیده
منابع مشابه
Narcotic Antagonists: The Search for Long-Acting Preparations, 4
S 7 DEVELOPMENT OF POLYLACTIC/GLYCOLIC ACID DELIVERY SYSTEMS FOR USE IN TREATMENT OF NARCOTIC ADDICTION A.D. Schwope, D.L. Wise, J.F. Howes 13 DEVELOPMENT OF INJECTABLE MICROCAPSULES FOR USE IN THE TREATMENT OF NARCOTIC ADDICTION C. Thies 19 LONG-ACTING NARCOTIC ANTAGONIST COMPLEXES A.P. Gray, W.J. Guardina 21 SUSTAINED RELEASE OF NALTREXONE FROM GLYCERIDE IMPLANTS M.F. Sullivan, D.R. Kalkwarf ...
متن کاملInjectable and implantable sustained release naltrexone in the treatment of opioid addiction.
Sustained release technologies for administering the opioid antagonist naltrexone (SRX) have the potential to assist opioid-addicted patients in their efforts to maintain abstinence from heroin and other opioid agonists. Recently, reliable SRX formulations in intramuscular or implantable polymers that release naltrexone for 1-7 months have become available for clinical use and research. This qu...
متن کاملNaltrexone HCI/bupropion HCI for chronic weight management in obese adults: patient selection and perspectives
Naltrexone, an opiate antagonist, and bupropion, a noradrenergic/dopaminergic antidepressant, have many effects on the reward systems of the brain. These medications impact eating behavior, presumably via their impact on food reward. However, only bupropion induces weight loss in obese individuals, while naltrexone does not have any appreciable effect. The combination of 32 mg of naltrexone and...
متن کاملBiodegradable polymeric prodrugs of naltrexone
The development of a biodegradable polymeric drug delivery system for the narcotic antagonist naltrexone may improve patient compliance in the treatment of opiate addiction. Random copolymers consisting of the a-amino acids N 5( 3-hydroxypropyl)-L-glutamine and L-leucine were synthesized with equimolar initial monomer feeds. The molecular weight of this chemical carrier was determined by viscom...
متن کاملThe preclinical development of Medisorb Naltrexone, a once a month long acting injection, for the treatment of alcohol dependence.
Oral naltrexone, a nonselective opioid antagonist, is approved for the treatment of alcohol and opioid dependence. However, the efficacy of oral naltrexone is limited by poor patient compliance. To overcome this limitation, attempts have been made to develop an injectable extended-release formulation of naltrexone, including encapsulation into biodegradable polymer microspheres (e.g. Medisorb N...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- NIDA research monograph
دوره 28 شماره
صفحات -
تاریخ انتشار 1981